Preliminary Programme

• Sunday, 1 March

  17:00-19:30	Arrival and registration
  19:30-19:45	Welcome word Géraldine Drexel De Buchy (Chief Executive Officer FVA)
  19:45	Drinks and buffet

• Monday, 2 March

  What is AD? What causes AD?
  Morning session chair: Frédéric Checler (Valbonne, France)
  8:00-8:20	Opening of the Workshop Robyn Koster (European Grant manager AFI-AN-FVA)
  8:20-8:55	Manuela Neumann (Tübingen, Germany) Neuropathology of dementias [30 min + 5 min discussion]
  8:55-9:30	Luc Buée (Lille, France) Which tau species for spreading and seeding among tauopathies [30 min + 5 min discussion]
  9:30-10:05	Florence Pasquier (Lille, France) Neuropsychological diagnosis/clinical symptoms [30 min + 5 min discussion]
  10:05-10:25	Discussion: Common denominators and specificities of proteinopathies and dementia
  10:25-10:45	Coffee break
  10:45-11:20	Milos Pekny (Gothenburg, Sweden) Neuro-immunological aspects of neurodegeneration [30 min + 5 min discussion]
  11:20-12:20	Peter St George-Hyslop (Cambridge, United Kingdom) The role of physiological and pathological biological condensates formed by intrinsically disordered proteins in neurodegenerative diseases [50 min + 10 min discussion]
  12:20-12:50	Harry Steinbusch (Maastricht, The Netherlands) Introduction to Grant Writing assignment [20 min + 10 min discussion]
  12:50-14:00	Lunch
  14:00-15:20	Parallel sessions: student Pecha Kuchas [6 min per student]
  15:20-22:30	Social activity and dinner

• Tuesday, 3 March

  What is new in AD concepts?  How can we study/model AD?
  Morning session chair: Paul Lucassen (Amsterdam, The Netherlands)
  8:00-8:45	Harry Steinbusch (Maastricht, The Netherlands) AD models – critical review [30 min + 5 min discussion + 10 min debate group 6]
  8:45-9:30	Henrietta Nielsen (Stockholm, Sweden / Roskilde, Denmark) Creating a human neurodegenerative disease in non-humans [30 min + 5 min discussion + 10 min debate group 5]
  9:30-10:15	Elly Hol (Utrecht, The Netherlands) Human post-mortem brain tissue and cerebral organoids to study glia in Alzheimer [30 min + 5 min discussion + 10 min debate group 4]
  10:15-10:35	Coffee break
  10:35-11:10	Anne-Laurence Boutillier (Strasbourg, France) Epigenetics and dementia [30 min + 5 min discussion]
  11:10-11:50	Marie-Christine Chartier-Harlin (Lille, France) Florence Pasquier (Lille, France) Interactive session: Alzheimer’s disease and related (?) diseases [40 min]
  11:50-12:25	Wiesje van der Flier (Amsterdam, The Netherlands) A changing diagnostic paradigm of Alzheimer’s disease; role of imaging and biomarkers [30 min + 5 min discussion]
  12:25-13:50	Lunch
  Afternoon session chair: Harry Steinbusch (Maastricht, The Netherlands)
  13:50-14:20	Robyn Koster (European Grant manager AFI-AN-FVA) European Network and organisations [15 min] Harry Steinbusch (Maastricht, The Netherlands) Grant Cycle review procedures. Tips & Tricks to write a good grant [15 min]
  14:20-19:00	Work on assignment in groups [coffee break at 16:00]
  19:00-21:30	Dinner (canteen)
  21:30-22:30	Stephan Schilling (Halle, Germany) Developing therapies for Alzheimer’s disease; hoops and hurdles from a biotech company perspective) [50 min + 10 min discussionn]

• Wednesday, 4 March

  How do we develop new treatments and drugs for AD? And why do so many trials fail?
  Morning session chair: Marie-Christine Chartier-Harlin (Lille, France)
  8:00-8:45	Paul Lucassen (Amsterdam, The Netherlands) Lifestyle factors and dementia – general introduction [30 min + 5 min discussion + 10 min debate group 3]
  8:45-9:30	Julien Chapuis (Lille, France) High-throughput approached to decipher genetic component of Alzheimer’s disease [30 min + 5 min discussion + 10 min debate group 2]
  9:30-10:15	Sheela Vyas (Paris, France) Gender in etiopathology of Alzheimer’s disease [30 min + 5 min discussion + 10 min debate group 1]
  10:15-10:35	Coffee break
  10:35-11:10	Annerieke Sierksma (Leuven, Belgium) Alzheimer risk genes drive the microglial response to amyloid-beta, not TAU, pathology [30 min + 5 min discussion]
  11:10-11:45	Frédéric Checler (Valbonne, France) Amyloid cascade: obsolete or poorly understood? [30 min + 5 min discussion]
  11:45-12:10	Discussion: Amyloid and the aetiology of Alzheimer’s Disease
  12:10-12:30	Q&A session on grant writing assessment [20 min]
  12:30-13:50	Lunch
  13:50-19:00	Work in groups on assignments [coffee break at 16:00]
  19:00-21:30	Pizza Party

• Thursday, 5 March

  9:00-12:30	Student presentations of grant proposals Reviewers: Elly Hol (Utrecht, The Netherlands) Luc Buée (Lille, France) Frédéric Checler (Valbonne, France) Paul Lucassen (Amsterdam, The Netherlands) Harry Steinbusch (Maastricht, The Netherlands) Thomas Arendt (Leipzig, Germany) Marie-Christine Chartier-Harlin (Lille, France) Annerieke Sierksma (Leuven, Belgium)
  9:00-9:30	Presentation group 1: Predictive Biomarkers (blood-based, imaging, etc) [15 min + 10 min discussion]
  9:30-10:00	Presentation group 2: Evidence-based preventions/risk-lowering practices [15 min + 10 min discussion]
  10:00-10:30	Presentation group 3: Inflammation and neuro-immunology [15 min + 10 min discussion]
  10:30-10:50	Coffee break
  10:50-11:20	Presentation group 4: Protein aggregation, seeding and spreading [15 min + 10 min discussion]
  11:20-11:50	Presentation group 5: Vascular contributions [15 min + 10 min discussion]
  11:50-12:20	Presentation group 6: Synaptic Biology and Neuroplasticity [15 min + 10 min discussion]
  12:20-12:50	Feedback from reviewers and students
  12:50-13:05	Award Ceremony and Closure of the Workshop
  13:05	Lunch (boxes provided)